The Origin of BPH and Prostate Cancer in Different Prostate Zones and the Impact on the Incidence of Prostate Cancer: A Systematic Review and Update of the Literature for Urologists and Clinicians

Background and objectivesNumerous clinical studies over recent years have reported an inverse relationship between benign prostatic hyperplasia (BPH) size the incidence of prostate cancer (PCa), leading to hypothesis that expanding BPH zone damages glandular tissue where PCa predominately develops. This systematic review aims establish a historical basis reference on zonal origin (PCa) within prostate.